产品货号：
Z39395
中文名称：
UBE3A抗体
英文名称：
Anti-UBE3A Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-UBE3A Antibody |
| 指标别名 | ANCR;AS;E6 AP;E6AP;E6AP ubiquitin protein ligase;EPVE6AP;HPVE6A;UBE3A;ubiquitin protein ligase E3A |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | UBE3A |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human UBE3A E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.Several substrates have been identified including the RAD23A and RAD23B,MCM7 (which is involved in DNA replication),annexin A1,the PML tumor suppressor,and the cell cycle regulator CDKN1B. |
| 实际分子量 | 100KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene.It is mapped to 15q11.2.This gene encodes an E3 ubiquitin-protein ligase,part of the ubiquitin protein degradation system.This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues.Maternally inherited deletion of this gene causes Angelman Syndrome,characterized by severe motor and intellectual retardation,ataxia,hypotonia,epilepsy,absence of speech,and characteristic facies.The protein also interacts with the E6 protein of human papillomavirus types 16 and 18,resulting in ubiquitination and proteolysis of tumor protein p53.Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini.Additional transcript variants have been described,but their full length nature has not been determined. |
| Uniprot ID | Q05086 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
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